Locked away in an asylum for a decade and teetering between life and death, the criminal mastermind Dr. Mabuse has scribbled his last will and testament: a manifesto establishing a future empire of crime. When the document's nefarious writings start leading to terrifying parallels in reality, it's up to Berlin's star detective, Inspector Lohmann, to connect the most fragmented, maddening clues in a case unlike any other.